Mitochondria - derived superoxide and voltage - gated sodium channels in baroreceptor 1 neurons from chronic heart failure rats
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چکیده
1 Mitochondria-derived superoxide and voltage-gated sodium channels in baroreceptor 1 neurons from chronic heart failure rats 2 3 Huiyin Tu, Jinxu Liu, Zhen Zhu, Libin Zhang, Iraklis I. Pipinos, Yu-Long Li 4 Department of Emergency Medicine, Surgery, and Cellular & Integrative Physiology, 5 University of Nebraska Medical Center, Omaha, NE 68198 6 7 *Equal contribution by these authors. 8 9 Short Running Title: Superoxide and sodium channel in neurons 10 11 Corresponding author: 12 Yu-Long Li, M.D., Ph.D. 13 Department of Emergency Medicine 14 985850 Nebraska Medical Center 15 Omaha, NE 68198-5850 16 Tel: 402-559-3016; Fax: 402-559-9659 17 E-mail: [email protected] 18 Articles in PresS. J Neurophysiol (November 9, 2011). doi:10.1152/jn.00754.2011
منابع مشابه
Mitochondria-derived superoxide and voltage-gated sodium channels in baroreceptor neurons from chronic heart-failure rats.
Our previous study has shown that chronic heart failure (CHF) reduces expression and activation of voltage-gated sodium (Na(v)) channels in baroreceptor neurons, which are involved in the blunted baroreceptor neuron excitability and contribute to the impairment of baroreflex in the CHF state. The present study examined the role of mitochondria-derived superoxide in the reduced Na(v) channel fun...
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تاریخ انتشار 2011